A central challenge in computational organogenesis is the coupling of the signaling network model to a tissue model. To model cellular processes such as cell orientation and migration, directed cell division and differentiation without increasing the level of abstraction, cell-based simulation techniques are required. It is a major goal of this thesis to provide a prototypic framework tailored to investigate morphogenetic problems in early embryogenesis. This includes the possibility to model both signaling networks and cell based tissue representations.
LBIBCell is a simulation software for physical tissue mechanics and biomolecular signaling models.